The Flanders Hotel in Ocean City is hosting a Dr. Seuss Birthday Party on Saturday, March 2, from 10 a.m. to noon.To begin with, attendees will enjoy a scrumptious buffet, which includes — What else? — Dr. Seuss’ favorite meal, green eggs and ham. There will also be story time, pictures with the Cat in the Hat and games and crafts.The cost is $29 per person, plus tax and gratuity. There is no charge for children under 2 years old.The Flanders is located at 711 E. 11th Street. Payment is due at time of reservations. For more information or to make a reservation, call 609-399-1000.
A defence ministry official speaking to AFP on condition of anonymity confirmed the army toll, while the provincial police spokesman Hejratullah Akbari confirmed the police fatalities.The insurgents also attacked police in central Uruzgan province Tuesday night, with the governor’s spokesman Zergai Ebadi telling AFP: “Unfortunately, six police were killed and seven wounded.”The violence has cast a pall on the nascent Afghan peace process, with the insurgents clashing with Kabul over a prisoner exchange ahead of talks that are due to begin on March 10.On Tuesday Trump told reporters in Washington that he had a “very good” relationship with Taliban political chief Mullah Baradar, with the pair speaking on the phone for 35 minutes, according to the insurgents. Taliban militants killed at least 20 Afghan soldiers and policemen in a string of overnight attacks, government officials told AFP Wednesday, hours after US President Donald Trump said he had a “very good” chat with their political chief.The militants have ramped up violence against Afghan security forces in recent days, ending a partial truce put in place during the run-up to a landmark US-Taliban withdrawal deal signed in Doha on Saturday. “Taliban fighters attacked at least three army outposts in Imam Sahib district of Kunduz last night, killing at least 10 soldiers and four police,” said Safiullah Amiri, a member of the provincial council. “The relationship is very good that I have with the mullah. We had a good long conversation today and you know, they want to cease the violence, they’d like to cease violence also,” he said.Trump has touted the Doha deal as a way to end the bloody, 18-year US military presence in Afghanistan — right in time for his November re-election bid.Under the terms of the deal, US and other foreign forces will quit Afghanistan within 14 months, subject to Taliban security guarantees and a pledge by the insurgents to hold talks with the national government in Kabul.The agreement also includes a commitment to exchange 5,000 Taliban prisoners held by the Afghan government in return for 1,000 captives — something the militants have cited as a prerequisite for talks but which President Ashraf Ghani has refused to do before negotiations start. ‘Common interest’ Trump said the Taliban and Washington both “have a very common interest” in ending the war.He had sharper words for Ghani’s government, however, suggesting they might be “reluctant” to pursue a deal.”They’ve done very well with the United States for many years — far beyond military if you look at all the money that we spent in Afghanistan,” he said.Since Saturday’s deal signing, the Taliban have been publicly claiming “victory” over the US and on Monday they announced they would resume attacks on Afghan national forces.The halt to the limited truce, which began on February 22, ended what was a welcome reprieve for ordinary Afghans who have born the brunt of the deadly violence. Ghani’s government last week sent a delegation to Qatar to open “initial contacts” with the insurgents, but Taliban spokesman Suhail Shaheen on Tuesday said the militants would not meet Kabul’s representatives except to discuss the release of their captives.Apparent differences between the Doha agreement and a separate joint US-Afghan declaration made in Afghanistan underline the obstacles facing negotiators.The US-Taliban deal committed to the release of prisoners, while the Kabul document only required both sides to determine “the feasibility of releasing” captives.Topics :
CLEAR LAKE — The City of Clear Lake has announced they’ll start spraying for mosquitoes as determined to be necessary. Spraying will tentatively occur between Monday evening and Saturday morning depending on the weather conditions, including wind speeds not being greater than 10 miles per hour. City staff will spray starting at 7:00 PM and continue as long as the temperature and wind speeds are at acceptable levels. Spraying may resume the following morning at 4:00 AM and end at about 7:00 AM. Spraying will continue throughout the summer and fall as long as the mosquito population counts justify the spraying. The city will also be spraying on the lake’s south shore in the Grand View Point, Bell Harbor, Dodges Point, Whispering Oaks and Camp Tanglefoot areas. Anyone not wanting the spraying to happen on their property must contact the city’s Operations and Maintenance supervisor Jeremy Korenberg at 357-6135. Additional information about the city’s mosquito spraying program can be obtained from the city’s website cityofclearlake.com
The company whose staff may have exposed up to 50,000 travelers to the coronavirus has had its contract for work at Port Everglades dropped by a popular cruise line.Three of the first four people who tested positive for the virus in Broward County worked for Metro Cruise Services, which provided guest services for Princess Cruises in Fort Lauderdale.Port Everglades spokeswoman Ellen Kennedy said Wednesday that Princess Cruises officials informed her they have stopped using the contractor and have replaced it with another company.On Tuesday, health officials revealed that three part-time employees of Metro Cruise Services tested positive for coronavirus.With that, travelers who were planning to board the Caribbean Princess on Wednesday for a 10-day trip to the Panama Canal were notified by email late Tuesday that their cruise was cancelled.The email attributed the cancellation to an anticipated shortage of labor at the port.Kennedy explains that Princess Cruises was concerned it might not have enough time to fill all the positions in time for Wednesday’s voyage.Princess Cruises will provide full refunds of the cruise fare and any related travel booked through the company, in addition to giving passengers full credit for a future cruise over the next year.The company also operates the Diamond Princess, which was quarantined for two weeks early this year in Japan after 700 of its passengers contracted coronavirus.In recent days, the Centers for Disease Control and Prevention had placed two Princess Cruises ships under “no-sail” orders, preventing them from docking at U.S. ports.One was the Caribbean Princess, which remained off the coast of Port Everglades after health officials discovered that two of the ship’s crew members had worked aboard its sister ship, Grand Princess, which was struck with coronavirus in California.Tests of the two Caribbean Princess workers came back negative, allowing the ship to dock before dawn Wednesday at Port Everglades.The cruise line’s next scheduled departure from that port is Saturday, when the Sky Princess is set to begin a seven-day Western Caribbean trip.
Two Boynton Beach officials have lost their jobs, after an art project in the city was changed to replace the images of two black former fire chiefs with white faces.City Manager Lori LaVerriere said in a statement on Saturday that she has terminated public arts manager Debby Coles-Dobay, and has also removed Matthew Petty as chief of the Boynton Beach Fire Rescue Department.A few hours later, LaVerriere added that she and Petty “agreed that it is in the best interest of the city of Boynton Beach that we mutually separate employment.”The move comes after a public mural that showed the images of two black former fire chiefs in the city was painted over with white faces.“The decision made to alter the artwork that was approved by the Public Arts Commission was wrong and disrespectful to our community,” LaVerriere wrote.She continued, “Every employee in the city of Boynton Beach works for its community. As a leader, I have been very clear that I will not tolerate any employee to be disrespectful, in any shape or form, to any members of our community.”LaVerriere also said the decisions “difficult but necessary.”
Advertisement gjNBA Finals | Brooklyn Vstozh1Wingsuit rodeo📽Sindre E5t9( IG: @_aubreyfisher @imraino ) 5sapfWould you ever consider trying this?😱i2sCan your students do this? 🌚q2Roller skating! Powered by Firework Despite the ongoing coronavirus crisis, the All India Football Federation (AIFF) is still confident of organising the FIFA Under-17 Women’s World Cup later this year. The global pandemic has resulted in postponement and cancellations of several sporting events around the world, with the 2020 Tokyo Olympic Games rescheduled to July next year. However, AIFF general secretary Kushal Das remains optimistic that the organising committee can prepare for the high-profile tournament with seven months at their disposal – even though the final decision depends on FIFA.Advertisement Picture Credit: AFC.com“Yes, there is still a lot of time left and we will wait and watch the developments in the coming time,” Das said in an interview.“FIFA will take a call on this, they are keeping a track of all the developments and we will see how it goes,” he added.Advertisement The U-17 Women’s World Cup is scheduled to start from November 2 onwards and the five cities of Navi Mumbai, Ahmedabad, Bhubaneswar, Guwahati and Kolkata have been selected as the venues.But following the Covid-19 outbreak, FIFA announced that they are currently monitoring the pandemic situation in India, while also exploring a few “alternative solutions”Advertisement “FIFA is currently monitoring developments regarding the coronavirus outbreak in India to decide the future of the U-17 Women’s World Cup which is slated to be held in the country in November,” the governing body declared via a press release.“FIFA is also working with the Local Organising Committee to identify any potential impact on preparations for the FIFA U-17 Women’s World Cup India 2020, as well as finding alternative solutions to upcoming events that were planned in India in the lead up to the tournament.”The World Cup will see sixteen teams participate for the coveted trophy, with only three nations sealing their spot till date.Being the hosts, Team India gained their automatic qualification; while the other two countries, North Korea and Japan progressed from the Asian qualifiers through the winner and runner-up spot respectively.Meanwhile, the Covid-19 pandemic has claimed over 38,000 lives throughout the planet, infecting further 7,50,000 more as of now.India on the other hand, have registered over 1400 positive cases with 40 deaths so far. You may also like:India granted the hosting status for the 2020 FIFA U-17 Women’s World CupDreamer to Ranger: All about Bala Devi, the Indian football tigress who joined Rangers in Scotland Advertisement
The Lakeside pitch near the Slopitch Ball Diamonds was once again a sea of soccer at Nelson Youth Soccer kicked off the fall season.Most leagues are back up and running during the final part of the house league season.Rep Teams were off to Revelstoke and Sandpoint, Idaho, for tournaments. The NYS House League season concludes the first weekend of October.
USL Results & Reports 11.08.13Results4 Lanterns USL Derry City Res. 1 0 Drumkeen Utd.(played in Drumkeen)DPD Couriers First DivisionLetterkenny Rovers 2 4 Swilly Rovers ReportsDrumkeen Suffer Title SetbackDrumkeen Utd. 0Derry City Res. 1Drumkeen’s quest for a first USL title took a knock at a rain soaked St Patrick’s Park as they lost one nil to the reigning champions. The home side started brightly and almost went in front on 8 mins when Conor Carlin delightfully controlled Packie Mailey’s long ball but the keeper saved well as the rebound fell to Carlin again but his shot from a tight angle rolled across goal. Carlin had another good chance moments later when Ronan Coyle chipped a delightful ball through but his first time shot was well blocked by the keeper. The home team continued to dominate and David Shovlin was just wide with a shot from the edge of the box. The visitors first shot of note was a tame shot from the Derry left back on 20 mins. The visitors came into the game after this and the remainder of the first half was a hard fought battle with chances at both ends hard to come by. Drumkeen home side were again on top from the restart and had a half chance on 50 mins when the keeper fumbled a harmless cross but he reacted well to get to the second ball. A min later Chris McBride was played in by Ronan Coyle but he dragged his shot wide of the far post. The home times best chance fell to Carlin when McBride crossed for Carlin but on the stretch his shot went over the bar from a few yards out. On 63 mins Michael Carroll headed a free into the box and Mark Marley headed goalwards but his effort lacked power. The visitors had a glorious chance on 65 mins when Tony McNamee cross but with the goal at his mercy no 8 missed his kick. The home team had another let off just a minute later when the keeper fumbled a tame shot but it just trickled wide. The let off was short lived as from the corner they scored with a header. Drumkeen had a chance on 75 mins when Carlin’s shot from Coyle’s ball was well saved. On 76 mins Carlin’s cross was headed straight at the keeper by Shovlin. Derry almost made it two on 79mins when the no 8 some how missed from 3 yards out. Drumkeen piled on the pressure after this but just could not get the goal they needed with Richie Moore having two good efforts blocked and Shovlin having a fine effort tipped over the bar. Best for Drumkeen Ryan Gildea, Mark Marley and Conor Carlin. First Division ReportSwilly Rovers Res. 4Letterkenny Rovers Res. 2A minutes silence was reserved prior to the game in memory of Mary O Donnell wife of Letterkenny Rovers coach Liam O Donnell who sadly passed away this week. Liam played for Swilly a number of seasons ago too. This was a very entertaining local derby with the Ramelton men emerging victorious. Letterkenny were very much on top in the first twenty minutes with strikers Darren McElwaine and Jason Doherty going close. Swilly then got to grips with midfield duo James Mc Cahill and Daniel O Donnell pulling the strings for Swilly in midfield. Shay Durning with a shot cut cross was deflected home by a Letterkenny defender on 21 minutes.On the stroke of half time, Daniel O Donnell scored a penalty to put Swilly two ahead. On 71 minutes, it was three after a brilliant move Daniel O Donnell released and Liam O Donnell with a superb cross was headed home with style by Kyle Black. James Mc Cahill then hit the crossbar with a superb drive. On 82 minutes Jonny Logue released Liam O Donnell who hammered home in some style to make it four. Kristin Ferris with two fine close rang efforts reduced the deficit to two in the final four minutes. Swilly had a man dismissed on 51 minutes but held on to record an impressive victory. Swilly Rovers: Caolan Bolton, Shay Durning, Ciaran Diver, Jonny Logue, Anthony Fisher, Ryan Mc Daid, James Mc Cahill, Daniel O Donnell, Callum Milner, Liam O Donnell, Oisin Duffy. Subs: Bobby Hanlon, Kyle Black, Jason Gibson(unused)Letterkenny Rovers: Chris O’Donnell, Brandon Toye, Noah Mailey, Kieran Doherty, Anthony Doherty, Tristan Ferris, Kevin Doran, Chris Malseed, Darren Mc Elwaine, Jason Doherty, Aaron Scanlon. Subs: Matthew O Rourke, Steve Apake, Glen Gallagher, Ryan Mc Laughlin, Conor Coll, Will Friel, Ryan Connelly.Match Referee: Stephen TonerFixtures4 Lanterns USLMonday, August 12th at 7:30pmFanad Utd. v Swilly RoversRef. V. McLaughlinTuesday, August 13th at 7pmLetterkenny Rovers v Kildrum TigersRef. C. McLaughlinSunday, August 18th at 2pmBonagee Utd. v Finn Harps Res.Ref. P. DuddyFanad Utd. v Cockhill CelticRef. P. CollKildrum Tigers v Derry City Res.Ref. W. HarveySwilly Rovers v Letterkenny RoversRef. T. McAreeDPD Couriers Div. 1 Cup Final at Leckview ParkSaturday, August 17th, Kick-Off 5pmDrumkeen Utd. Res. v Swilly Rovers Res.Ref. V. McLaughlinAssts. C. McLaughlin & M. Lagan4 Lanterns Ulster Senior LeagueTeamPWDLForAgainstDiff +/-PointsDrumkeen Utd.11100124121230Cockhill Celtic118302662027Letterkenny Rovers104421412216Swilly Rovers94231712514Kildrum Tigers93331813512Derry City Res.113261518-311Finn Harps Res.111551420-68Fanad Utd.101271029-195Bonagee Utd.101181429-154DPD Couriers USL First DivisionTeamPWDLFADiff +/-PointsKildrum Tigers65011641215Swilly Rovers53021112-19Bonagee Utd.52121013-37Letterkenny Rovers6204911-26Drumkeen Utd.5113812-44SOCCER: ULSTER SENIOR LEAGUE REPORTS was last modified: August 11th, 2013 by John2Share this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)
Proteins need a protected space to fold, and the cell provides it: the GroEL-GroES chaperone (see 05/05/2003, 06/07/2006, and 02/13/2007). More details keep coming in about this “protein dressing room” as scientists continue to probe its secrets. Two new papers in PNAS by a team at University of Maryland and College Park reveal that this is no passive cavity. The system acts like a two-stroke engine with two timers.1,2 John P. Grason et al have examined the machinery in action, and found truly amazing properties in this tiny but complicated system. We’ll try here to reduce their complex jargon into easily-pictured analogies. To picture GroEL, think of two donut-shaped rings, studded with electronics, that stack on top of one another. We’ll call them cis and trans. The cis ring on the bottom has a floor, while the trans ring is open. When stacked, they form a barrel-shaped cavity. On top, another protein called GroES fastens and forms a protective cap. Now we have something like a scuba diver’s emergency decompression chamber, if you can picture it. A good decompression chamber is going to keep the patient inside long enough, but not too long. Humans can control their chambers, but how does a sightless nanomachine do it? The answer: through the use of timers. There are two timers in the GroEL-GroES system that operate independently. Working together, they optimize the time the protein inside has for folding, without letting the prima donna hog the dressing room when others need to use it (sorry for the mixed metaphors). How the system accomplishes this is truly astonishing. Deploying ATP energy, the two rings twist back and forth against each other, creating strain. They undergo a two-stroke cycle: starting in phase, then twisting 180° with respect to each other, then back again. The authors call the stages taut (T) and relaxed (R); when cis is taut, trans is relaxed, and vice versa. Their two-stroke cycle time is dependent on the protein inside the barrel and on the presence of ATP and potassium ion. This gives the operation some flexibility. The protein in the dressing room isn’t unnecessarily rushed, and the chamber isn’t wasting energy when no one is inside. The other timer, though, is like a countdown timer with no mercy. In the floor of the cis ring, a second timer running on ATP has a time limit that starts when the lid closes. When the timer hits zero, the protein is booted out, folded or not (see footnote 3). Working together, these two timers optimize the protein folding time. The variable timer, like an idling engine, goes to work when the protein enters. It tries to adjust its time to the needs of the protein inside. But if the protein doesn’t finish folding in the 3-to-4 second window of the second timer, it gets ejected. It can, however, come back in for a second try. The protein can keep trying, in fact, till it succeeds or gives up and gets recycled by the trash collection process (a “very sophisticated recycling system” described this week on PhysOrg). Here’s how the authors describe how the timers interact:In the absence of SP [substrate protein inside the cavity], the chaperonin machine idles in the resting state, but in the presence of SP it operates close to the speed limit, set by the rate of ATP hydrolysis by the cis ring. Thus, the conformational states [i.e., twisting motions] of the trans ring largely control the speed of the complete chaperonin cycle.What this means is that every actor gets a shot at the dressing room, but those with more costuming and make-up (i.e., more complex proteins) get more time – within limits. If it exceeds the upper limit it has to go back outside and wait for another turn. The authors called this flexible mechanism, which coordinates a variable timer with a non-variable timer, “iterative annealing.” They said iterative annealing is “simply a biological example of a well known and widely used principle of optimization.” Maybe public shower operators could learn something here. Analogies have their limitations, but to show that we are not making this up, here is the summary explanation in their own words. Look for a hint of excitement in their discovery:The picture of the chaperonins that emerges from our work is that of a machine equipped with a timer, the trans ring, poised to respond to the appearance of SP [substrate protein inside the cavity] but otherwise idling in a quiescent state. We note that Nature’s design of this 2-speed protein machine minimizes the hydrolysis of ATP in the absence of SP. However, it maximizes the number of turnovers and minimizes the residence time available to the encapsulated SP to reach the native state, design principles well suited to the operation of an iterative annealing device.How did this system arise? One of the papers began with an oblique reference to evolution that raises more questions than it answers: “As with many other cellular machines, the chaperonin nanomachine has evolved to operate at variable speed in response to biological demand.” This puzzling statement seems to imply teleology – a sin in the world of Darwinian explanations. In neither paper, however, did the authors speculate on how a blind, purposeless process could have produced an optimized system as functionally efficient and complicated as the GroEL-GroES chaperone. Quite the contrary. The quote above used the word Design twice.Note: Both papers are categorized as Open Access and can be read in their entirety online; see footnotes.1. Grason, Gresham, Widjaja, Wehri and Lorimer, “Setting the chaperonin timer: The effects of K+ and substrate protein on ATP hydrolysis, Proceedings of the National Academy of Sciences USA, published online before print November 6, 2008, doi: 10.1073/pnas.0807429105 (open access article).2. Grason, Gresham and Lorimer, “Setting the chaperonin timer: A two-stroke, two-speed, protein machine,” Proceedings of the National Academy of Sciences USA, published online before print November 6, 2008, doi: 10.1073/pnas.0807418105 (open access article).3. The famous adventurer John Muir as young man invented a bed that would raise up when the alarm went off, putting the surprised sleeper on his feet.Don’t get too mad at Dr. Grason for putting the E-word into the paper. If he hadn’t paid homage to Charlie’s Totalitarian Regime, he might have been Expelled. At least there is progress: the D-word outscored the E-word two to one. What a great day it will be when scientists are free to express joy at the designs they explore without having to say stupid things like “it evolved” (05/25/2005 commentary).(Visited 56 times, 1 visits today)FacebookTwitterPinterestSave分享0
By: David Lee Sexton, Jr.Pexels [Symbol Tree on October 31, 2016, CC0]Alaina Szlachta, Ph.D.Dr. Szlachta is a scholar and practitioner who intersects the academic world of rigorous research and interdisciplinary teaching with the private sector. Dr. Szlachta is currently the Director of Training with the National Domestic Violence Hotline, where she developed the Hotline’s 60-hour Domestic Violence Advocacy Training Program and facilitates training on healthy relationships, intimate partner violence, and culturally responsive practice.Fostering Healthy Relationships in Military FamiliesIn an insightful 90-minute webinar, Szlachta (2016) explores characteristics that define both healthy and unhealthy relationships. Furthermore, the differences between unhealthy and abusive relationships are explored, and guidance is presented for mental health professionals working with clients who may be in abusive relationships. For example, Szlachta discusses clues to look out for which may indicate to a mental health professional that it is time to have a conversation about the health of a client’s relationship. In addition, Szlachta identifies specific challenges military service members face in maintaining healthy relationships and provides strategies service members and their families can use to tackle the specific challenges they face, such as creating emotional safety plans.What Previous Viewers Have to SayYou don’t have to just take it from us that this was an insightful and useful webinar. Here are some things that our participants had to say about this webinar:“I loved the idea of having an ’emotional safety plan’ for our military families.”“I participate in a couple of webinars monthly and this was really one of the best I’ve heard lately. The amount of interaction in the chat panel was encouraging and the leader was open to interaction vs. simply reading from the slides. Really enjoyable and learned a lot. Thank you. “Want to Learn More?To learn more about maintaining healthy relationships, please take some time to watch the MFLN Family Development Team’s free, archived webinar presented by Alaina Szlachta, Ph.D.Also, get social with us on Facebook and Twitter to learn about more great content, webinars, and free CEU opportunities in the future.ReferencesSzlachta, A. (2017). On solid ground: Exploring strategies to help clients create and maintain healthy relationships. MFLN Family Development. Retrieved from: https://militaryfamilieslearningnetwork.org/event/27283/.This post was written by David Lee Sexton, Jr. of the MFLN Family Development Team. The Family Development team aims to support the development of professionals working with military families. Find out more about the Military Families Learning Network Family Development team on our website, Facebook, and Twitter.