Brazil coach Tite extends contract until 2022 World Cup

first_imgFILE – In this June 16, 2018 file photo, Brazil head coach Tite answers questions during a press conference during the 2018 soccer World Cup at the Rostov Arena in Rostov-on-Don, Russia. Tite has extended his contract with the team until the 2022 World Cup in Qatar, the Brazilian football confederation made the announcement on Wednesday, July 25. (AP Photo/Felipe Dana, File)SAO PAULO — Brazil coach Tite has extended his contract until the end of the 2022 World Cup in Qatar, the national football confederation said on Wednesday.Tite, 57, who has been in charge since August 2016, is the first Brazil coach to extend his deal after a World Cup since Claudio Coutinho in 1978.ADVERTISEMENT His team was knocked out by Belgium in the quarter-finals in Russia earlier this month but, unlike other national coaches, he has received little criticism since arriving home.Tite has a record of 20 wins, four draws and two losses at the helm.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkSPORTSTim Cone still willing to coach Gilas but admits decision won’t be ‘simple yes or no’Coordinator-general Edu Gaspar has also had his contract extended until the next World Cup.Brazil’s next matches are friendlies on Sept. 7 and 11 in the United States. The first is against the U.S., the second against a team as yet undecided. Putin’s, Xi’s ruler-for-life moves pose challenges to West Palace OKs total deployment ban on Kuwait OFWs In fight vs corruption, Duterte now points to Ayala, MVP companies as ‘big fish’ Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Tour de France: Froome crashes after police mistake him for fan LATEST STORIES Trump assembles a made-for-TV impeachment defense team MOST READ The team’s next big tournament is the 2019 Copa America, an event it will host.“The experience of this first cycle has established a relationship of trust among us all, and that will reflect in our next step,” Tite said in a statement.“It is a great challenge and we are happy to face it, we are already focused on the next matches and tournaments.”Brazilian football confederation chairman Rogerio Caboclo said the extensions were “part of a long-term project” that will give the team “careful planning” ahead of the next World Cup.ADVERTISEMENT Lacson: Calamity fund cut; where did P4 billion go? Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew DepEd’s Taal challenge: 30K students displaced Report: Disney dropping the ‘Fox’ from movie studio names ‘High crimes and misdemeanors’: Trump impeachment trial begins View commentslast_img read more

Female Palms’ Independence treat

first_img…”This is all a part of sharing the love and spirit of independence” – First Ladyn observance of Guyana’s 50th Independence Anniversary, First Lady Sandra Granger involved in the jointThe First Lady presenting a duster to a female resident at the Palms Geriatric Homeinitiative by the Ministry of Social Protection and the Women Across Differences (WAD) group, visited female members at the Palms Generic Home. According to the press release, the First Lady and Minister of Social Protection Volda Lawrence, made a contribution of 96 sets of bed linens and dusters for the women of the home on Wednesday, after having treated them to a special spa session of manicures, pedicures and hairdos on Monday. “This is all part of sharing the love and spirit of Independence, it is also an inter-generational activity because the girls from WAD were able to meet with seniors they might not have met in their ordinary lives and I think they had a good time,” said the First Lady. In the release, Lawrence highlighted that the move to treat and pamper the women of the Palms was conceived with the intention of bringing joy and remembering the less privileged during the celebration of Guyana’s Golden Jubilee, adding that there is hope for a similar initiative to be conducted on Fathers’ Day for the male residents there. “We are celebrating and in order to celebrate you have to prepare and this is just one of the ventures that we have partnered with NGOs and other organizations to ensure we bring cheer to the persons whom we are given the permission to care for,” the Minister of Social Protection voiced.Meanwhile, in a speech of appreciation, representative of WAD, Ann Greene said: “We give thanks to the First Lady for this initiative and we at Women Across Differences will continue to work with her. It was a very good experience with the girls. The girls got to speak with the women about what was going on in 1966. I think it was very encouraging. They enjoyed interacting with the ladies and all the ladies were very accommodating to the girls.”last_img read more

2 Women Birth ‘Strange Creatures in Bassa

first_imgBy Folo-Glagba KorkollieThe Daily Observer newspaper’s Grand Bassa County office in Buchanan has received information about two women giving birth to ‘strange creatures’ at separately locations recently in Glakon Statutory District #2 ‘A’.Martha Joe, a midwife told this newspaper at the scene of where the women were reportedly delivered that since she and her team of trained traditional midwives started delivering women about 15 years ago, they have never experienced such ‘extraordinary creatures’ coming out of any woman’s stomach.According to the Midwife narration, the first woman, Joan Kpah, was in her 10th month when she gave birth to a creature that was in the form of a ‘black cobra.’ “Just in time Madam Kpah was in labor pain, we suddenly observed a long black cobra-like living creature coming out of the woman’s stomach.The situation terrified us to the extent that we were thinking the snake would bite any of us, but that was to the contrary,” the midwife said.The traditional birth attendants killed the creature, and were also happy in the end because the expectant mother survived the ordeal.Marpue Gaye, the second woman, was said to have carried the pregnancy for 12th months in Goegbahn Township near the SOS Children’s Village when she too reportedly delivered a baby girl, but the baby had three horns on her forehead.The midwife described the three horns that were in the form of hair attachment, including one ear and two long teeth; one attached to the upper gum and the other at the lower one.The three-horned baby died few minutes after it was born, and subsequently was buried.Terrified residents, who witnessed the scenarios, described the two ‘births as extra-ordinary,’ blaming the ‘demons’ or witchcraft activities in the district being applied at the highest level.But a long standing medical practitioner, speaking to the Daily Observer, said such birth as the horned baby can be attributed to abnormal fetal development. According to him, Environmental factors, such as infectious diseases, drugs, chemicals, and radiation, have been shown to cause abnormal development by inducing chromosome abnormalities, specific gene changes, vascular changes, or mechanical disruption.This branch of medicine is called Teratology which is the study of the causes, mechanisms, and manifestations of abnormal fetal development.In many traditional societies including those in Liberia, such birth defects are usually attributed to witchcraft and it would not be surprising if the surviving mothers face ostracizationShare this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)last_img read more

More than 500,000 flee fires

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREGame Center: Chargers at Kansas City Chiefs, Sunday, 10 a.m.“This is the largest mass evacuation of a natural disaster in California history,” said Daniel Berlant of the Department of Forestry and Fire Protection. In San Diego County, authorities placed evacuation calls to more than 346,000 homes, said Luis Monteagudo, a spokesman for the county’s emergency effort. The county estimates, based on census tracts, that approximately 560,000 people were ordered to leave, said Ron Roberts of the San Diego Board of Supervisors. To the northeast, fires in the San Bernardino mountains forced the evacuation of entire communities surrounding the resort area of Lake Arrowhead. Thousands of people, including hospital patients, were forced to flee advancing flames that leaped through the mountains, burning one home after another, destroying at least 300 and threatening as many as 10,000 more, said U.S. Forest Service spokeswoman Gina Sampson. In neighboring Orange County, a fire chief lashed out at state officials, saying air support, such as tankers, might have helped control fires early on, before they burned homes, if it had been available. By Allison Hoffman and Gillian Flaccus THE ASSOCIATED PRESS SAN DIEGO – Deadly, wind-whipped wildfires have triggered the largest evacuation in state history, prompting more than 500,000 people to flee ahead of flames that destroyed more than 1,300 homes and continued Tuesday to threaten tens of thousands more. The number of people joining the mandatory exodus – and the number of homes destroyed – was expected to grow as new fires started and others continued to burn a path toward the sea – through populated communities. “There is not enough resources to go around ? because of the number of fires that are going on in our state right now,” said Orange County Fire Authority Chief Chip Prather. He said a dozen firefighters battling blazes in the Irvine and Lake Forest areas had to deploy emergency shelters, a last resort when they are surrounded by flames, or take cover in buildings. “They should not have had to do that,” he said. “If we’d had the resources earlier to take care of those lines with hand crews, we wouldn’t have been in that situation.” Prather’s comments came minutes before Gov. Arnold Schwarzenegger, touring fire damage in Lake Arrowhead, promised more help, including more people and equipment. When asked about the fire chief’s critical remarks, the governor said: “I’m not aware of that.” Berlant defended his agency’s actions, saying it had gone on high alert late last week and shifted resources to the San Diego area in advance of the forecasted Santa Ana winds. Meanwhile, in San Diego County, site of the only death so far, another 530 homes were reported damaged. Besides the one person killed by the flames, the San Diego Medical Examiner’s Officer listed four deaths as connected to the wildfires. Three were people in their 90s who died from natural causes; the fourth was a woman who died after falling at a restaurant. All are considered fire-connected deaths because they occurred during or after evacuations. The fire victim was identified as Thomas Varshock of Tecate, a town on the U.S. side of the border southeast of San Diego, the San Diego County Medical Examiner’s Office said. Authorities had told him to evacuate, but he didn’t leave and authorities left to take care of other evacuations, the Medical Examiner’s Office said. There were 45 injuries reported throughout Southern California, including at least 21 firefighters. The University of California, San Diego Medical Center Regional Burn Center was treating 16 patients from the San Diego County fires, including three firefighters and four others in critical condition. With some 410,000 acres, or 642 square miles, ablaze, President Bush declared a federal emergency for seven Southern California counties, a move that will speed disaster-relief efforts. He also scheduled a visit to the region on Thursday. Meanwhile, the Department of Defense agreed to send six Air Force and Air National Guard water- or retardant-dropping planes. Fire crews and fleeing residents described desperate conditions that were sure to get worse. Temperatures across Southern California were about 10 degrees above average and approached 100 degrees Tuesday in Orange and San Diego counties where Santa Ana winds gusted in some areas to 65 mph. The fires were exploding and shooting embers before them in all directions, preventing crews from forming traditional fire lines and greatly limiting aerial bombardment. In Orange County, flames tore through Modjeska Canyon, destroying homes after forcing firefighters to take cover. By Tuesday evening, some 50,000 people in San Diego were being allowed to return home, Roberts said. Many returned to two evacuated neighborhoods in San Diego – Del Mar Heights, near the ocean, and Scripps Ranch – as well as an evacuated portion of the city of Poway. At Marine Corps Air Station Miramar, about 40 aircraft that included F-18 fighter jets, C-130 cargo planes and Marine helicopters were evacuated to other bases in California and Arizona. Schwarzenegger, Homeland Security Secretary Michael Chertoff, Federal Emergency Management Agency Administrator R. David Paulison and other officials toured burn areas in San Diego and the evacuation center at Qualcomm Stadium before holding a brief news conference. “If the weather cooperates, maybe we can turn the tide (Wednesday),” Chertoff said, adding “hopefully the wind will die down,” so firefighting aircraft grounded by strong gusts could return to the skies. State insurance commissioner Steve Poizner said he was taking steps to combat the fallout of the fires, including sending his department’s numerous services experts and fraud teams to the region and working with insurance companies to accelerate payments. Agriculture Undersecretary Mark Rey, who oversees the Forest Service, predicted Tuesday that the fires could cost federal, state and local governments more than $100 million. Full containment of the San Diego fires may not occur before Nov 1.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more

RAPHOE CLUB’S UNIQUE DRAW MAKES LOTS OF “CENTS”!

first_imgTullyvinney Rovers F.C. from Raphoe have launched a unique fundraising charity draw on behalf of Donegal Hospice.The club is holding a blind draw with the proceeds shared with the Donegal Hospice.Unusually tickets are priced from 1 cent, 2 cent, upwards in 1 cent increments up to 20 euro, tickets are sealed in envelopes, so you won’t know what price your ticket is until you open your chosen envelope. The prizes are €2000, €1000, €500 and €300, so you could be really lucky and win €2000 for as little as a few cents.“Keep your eye out for our ticket sellers in your area, they are not collecting rubbish with their black bin, just your cash,” said a club spokesman.For more information or tickets please telephone 0868835453 or message Tullyvinney Rovers on facebook http://www.facebook.com/tullyvinney.roversRAPHOE CLUB’S UNIQUE DRAW MAKES LOTS OF “CENTS”! was last modified: July 2nd, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:donegal hospiceRaphoeTullyvinney Roverslast_img read more

Donegal man ‘dresses up’ for Darkness Into Light Falcarragh! – Picture Special

first_imgLocal man Frankie Connolly turned heads when he walked for Darkness Into Light Falcarragh in aid of Pieta House this year.While most participants put on the themed yellow shirt, Frankie wore an eye-catching striped dress. His unusual clothing choice wasn’t a mistake made in the early hours of the morning either – it was for a very special reason.Frankie launched a fundraising campaign in memory of his mother Teresa, who died tragically four years ago. He described in his fundraising appeal that his family suffered suicide in the past, and it was through his work as a psychiatric nurse that he was able to deal with the devastation.Frankie set a specific challenge to generate some interest around his fundraiser and attempt to reach a high target:“Just for the craic if I manage to hit the €3000 mark for this wonderful charity I’ll do the whole thing in my wife’s dress!!”, he promised.When the day arrived Frankie had gathered the impressive amount and had no other choice but to join the 600 other walkers in Falcarragh while wearing the dress. Frankie went above and beyond his target, and has raised €3,357 to date to support the life-saving services of Pieta House.Falcarragh’s Darkness into Light was a particularly special event as the group walked through the forest on the grounds of Ballyconnell Estate as dawn broke through the trees. €15,100 was raised at the venue. with still donations being collected.Committee member Annemarie Doohan said: “It’s just unreal the support from the community that we received, from participants wanting to help out on the morning off and all our local sponsors in Falcarragh, Ghaoth Dobhair and Dunfanaghy.”There were over 150,000 participants worldwide in Darkness Into Light 2017 – from Sydney to Dublin to Vancouver. Organisers are now close to hitting the €1 million mark and are this week asking everyone to make one last “post-event” fundraising ask friends, family and colleagues to donate to their individual pages. Visitdil.pieta.ie to find participants to sponsor.Donegal man ‘dresses up’ for Darkness Into Light Falcarragh! – Picture Special was last modified: May 12th, 2017 by Rachel McLaughlinShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:charityDarkness into LightFalcarraghfundraiserin memorylast_img read more

DONEGAL SFC GROUP 3: CLOUGHANEELY V GLENFIN PREVIEW

first_imgGAA: Cloughaneely host Glenfin in what is a must-win game for both sides this weekend following losses in their respective Donegal SFC openers.Intermediate championship winners last year Cloughaneely suffered a disappointing defeat to local rivals St Michael’s in their clash back in May. Glenfin also suffered a disappointing defeat at home to Four Masters and now face a tough challenge this Sunday against Cloughaneely.Cloughaneely have lost the services of influential duo John Fitzgerald and John McGarvey who went to the USA for the summer. Both players played pivotal roles for Cloughaneely last season and manager John Paul Gallagher will find it difficult to fill the void left by their absence.However, he still can call on the likes of Denis Boyle, Kevin Mulhern, Declan McKeever and Declan McGarvey to give his side the quality and experience they need to keep their championship hopes alive. Glenfin are bottom of Division Two and have endured a horror campaign thus far in the league.They suffered a very heavy defeat away to St Naul’s last weekend and confidence will be low in the camp ahead of their trip to Cloughaneely.Glenfin rely heavily on Donegal star Frank McGlynn and they will need him to be at his best on Sunday afternoon.However, with home advantage and more quality forwards Cloughaneely should have too much for Glenfin.Verdict: Cloughaneely DONEGAL SFC GROUP 3: CLOUGHANEELY V GLENFIN PREVIEW was last modified: August 20th, 2015 by Mark ForkerShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Donegal SFCGAASportlast_img read more

ON YOUR MARKS FOR DONEGAL ATHLETICS BOARD 5K

first_imgThe Donegal Athletics Board will host its annual 5K Race, Fun Run and Walk this Sunday 15th September in Letterkenny with a start time of 11.30am.This is the only race organised and run by the Donegal Board with all monies generated going back into the development of grassroots athletics in the county.Yet again, 2013 has been a super year for road running with a huge interest both in competitive and recreational races throughout the county. The County Board has been to the forefront of promoting and supporting races in Donegal, which have been organised by athletic clubs, and other sporting, community and voluntary organisations (and which in themselves have raised valuable monies for local causes).More than 600 attended the 2012 race in Convoy with the inaugural Shane Bonner Memorial Trophy unveiled following the young Convoy athletes tragic death last year. While this race attracts most of the county’s top athletes, the event is also designed to attract Fit4Life Groups, Road Running groups, recreational runners and walkers. A Team event adds an extra competitive edge to the race.Registration Desks open at 10am at the Leisure Centre in Letterkenny. The event will be ‘Chip Timed’.Participants are strongly encouraged to pre register their details to speed up number and chip collection on the morning of the race. Simply email your name, age category, gender and club (if any) to donegalathleticsboard@gmail.com or send a message via the DonegalAthleticsBoard Facebook page. Spread the word among family and friends and we look forward to seeing everyone there next Sunday. ON YOUR MARKS FOR DONEGAL ATHLETICS BOARD 5K was last modified: September 13th, 2013 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:5kDONEGAL ATHLETIC BOARDlast_img read more

WIN: A 49” TV from Irwin Expert Electrical just in time for Christmas

first_imgThe huge Black Friday Sale is NOW ON at Irwin Expert Electrical Letterkenny and Buncrana.It’s their biggest ever sale, with up to 50% OFF selected items in all Departments. Stocks are limited so get in early to bag deals on TVs, Home Appliances, Built In Appliances, Computers, Laptops, Small Kitchen Appliances and much more all reduced. The sale ends at 5.30pm on Saturday 30th November.And as an extra Christmas gift for one lucky customer, Irwins are giving you a chance to WIN a 49″LG TV!Paddy explains more in this video: Click here to enter the giveaway now: https://www.facebook.com/irwinexpert/photos/a.210925912351567/2398802396897230/Irwin Expert Electrical are the No. 1 Home Electrical Appliance Centres in the North WestIrwin Expert Electrical’s Christmas Club is open and will be delighted to help you choose the perfect Gift, you can pay in for it & collect by Christmas. They also accept SHOP LK vouchers. They are so thankful to their customers for shopping local and choosing Irwin Expert Electrical as their preferred Home Appliance, TV, Computer Centre & Household Electrical Retail Store for in the North West.Irwin Expert Electrical Letterkenny Showroom – Port Road, Letterkenny (Behind Browne Printers – Opposite Letterkenny Institute of Technology.Irwin Expert Electrical Buncrana Showroom – Maginn Avenue, Buncrana.Follow Us on Facebook : @irwinexpertWIN: A 49” TV from Irwin Expert Electrical just in time for Christmas was last modified: November 22nd, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Black FridaycompetitionIrwin Expert Electricalwin a tvlast_img read more

Cell Chaperone Is an Optimized Two-Stroke Machine

first_imgProteins need a protected space to fold, and the cell provides it: the GroEL-GroES chaperone (see 05/05/2003, 06/07/2006, and 02/13/2007).  More details keep coming in about this “protein dressing room” as scientists continue to probe its secrets.  Two new papers in PNAS by a team at University of Maryland and College Park reveal that this is no passive cavity.  The system acts like a two-stroke engine with two timers.1,2     John P. Grason et al have examined the machinery in action, and found truly amazing properties in this tiny but complicated system.  We’ll try here to reduce their complex jargon into easily-pictured analogies.  To picture GroEL, think of two donut-shaped rings, studded with electronics, that stack on top of one another.  We’ll call them cis and trans.  The cis ring on the bottom has a floor, while the trans ring is open.  When stacked, they form a barrel-shaped cavity.  On top, another protein called GroES fastens and forms a protective cap.  Now we have something like a scuba diver’s emergency decompression chamber, if you can picture it.    A good decompression chamber is going to keep the patient inside long enough, but not too long.  Humans can control their chambers, but how does a sightless nanomachine do it?  The answer: through the use of timers.  There are two timers in the GroEL-GroES system that operate independently.  Working together, they optimize the time the protein inside has for folding, without letting the prima donna hog the dressing room when others need to use it (sorry for the mixed metaphors).  How the system accomplishes this is truly astonishing.    Deploying ATP energy, the two rings twist back and forth against each other, creating strain.  They undergo a two-stroke cycle: starting in phase, then twisting 180° with respect to each other, then back again.  The authors call the stages taut (T) and relaxed (R); when cis is taut, trans is relaxed, and vice versa.  Their two-stroke cycle time is dependent on the protein inside the barrel and on the presence of ATP and potassium ion.  This gives the operation some flexibility.  The protein in the dressing room isn’t unnecessarily rushed, and the chamber isn’t wasting energy when no one is inside.  The other timer, though, is like a countdown timer with no mercy.  In the floor of the cis ring, a second timer running on ATP has a time limit that starts when the lid closes.  When the timer hits zero, the protein is booted out, folded or not (see footnote 3).    Working together, these two timers optimize the protein folding time.  The variable timer, like an idling engine, goes to work when the protein enters.  It tries to adjust its time to the needs of the protein inside.  But if the protein doesn’t finish folding in the 3-to-4 second window of the second timer, it gets ejected.  It can, however, come back in for a second try.  The protein can keep trying, in fact, till it succeeds or gives up and gets recycled by the trash collection process (a “very sophisticated recycling system” described this week on PhysOrg).  Here’s how the authors describe how the timers interact:In the absence of SP [substrate protein inside the cavity], the chaperonin machine idles in the resting state, but in the presence of SP it operates close to the speed limit, set by the rate of ATP hydrolysis by the cis ring.  Thus, the conformational states [i.e., twisting motions] of the trans ring largely control the speed of the complete chaperonin cycle.What this means is that every actor gets a shot at the dressing room, but those with more costuming and make-up (i.e., more complex proteins) get more time – within limits.  If it exceeds the upper limit it has to go back outside and wait for another turn.  The authors called this flexible mechanism, which coordinates a variable timer with a non-variable timer, “iterative annealing.”  They said iterative annealing is “simply a biological example of a well known and widely used principle of optimization.”  Maybe public shower operators could learn something here.    Analogies have their limitations, but to show that we are not making this up, here is the summary explanation in their own words.  Look for a hint of excitement in their discovery:The picture of the chaperonins that emerges from our work is that of a machine equipped with a timer, the trans ring, poised to respond to the appearance of SP [substrate protein inside the cavity] but otherwise idling in a quiescent state.  We note that Nature’s design of this 2-speed protein machine minimizes the hydrolysis of ATP in the absence of SP.  However, it maximizes the number of turnovers and minimizes the residence time available to the encapsulated SP to reach the native state, design principles well suited to the operation of an iterative annealing device.How did this system arise?  One of the papers began with an oblique reference to evolution that raises more questions than it answers: “As with many other cellular machines, the chaperonin nanomachine has evolved to operate at variable speed in response to biological demand.”  This puzzling statement seems to imply teleology – a sin in the world of Darwinian explanations.  In neither paper, however, did the authors speculate on how a blind, purposeless process could have produced an optimized system as functionally efficient and complicated as the GroEL-GroES chaperone.  Quite the contrary.  The quote above used the word Design twice.Note: Both papers are categorized as Open Access and can be read in their entirety online; see footnotes.1.  Grason, Gresham, Widjaja, Wehri and Lorimer, “Setting the chaperonin timer: The effects of K+ and substrate protein on ATP hydrolysis, Proceedings of the National Academy of Sciences USA, published online before print November 6, 2008, doi: 10.1073/pnas.0807429105 (open access article).2.  Grason, Gresham and Lorimer, “Setting the chaperonin timer: A two-stroke, two-speed, protein machine,” Proceedings of the National Academy of Sciences USA, published online before print November 6, 2008, doi: 10.1073/pnas.0807418105 (open access article).3.  The famous adventurer John Muir as young man invented a bed that would raise up when the alarm went off, putting the surprised sleeper on his feet.Don’t get too mad at Dr. Grason for putting the E-word into the paper.  If he hadn’t paid homage to Charlie’s Totalitarian Regime, he might have been Expelled.  At least there is progress: the D-word outscored the E-word two to one.  What a great day it will be when scientists are free to express joy at the designs they explore without having to say stupid things like “it evolved” (05/25/2005 commentary).(Visited 56 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more